Low-Grade Chronic Inflammation

The “Secret Killer”

Low-Grade Chronic Inflammation is a silent condition that goes unnoticed and can kill. A strong immune system helps fight viruses and bacteria. For this reason we devised an anti-inflammaging ecosystem which will distance people from diseases generated by inflammation and premature ageing.

 

The silent inflammation which keeps gaining momentum: 

It is linked to COVID-19 severity* cases

It is the major cause of premature

deaths globally**

Research of the past two decades led to the

discovery that low-grade inflammation is the common soil of many diseases and, thus, at the root of many deaths. Through its reduction of immune fitness, low-grade inflammation is also believed to be instrumental in the development of severe COVID-19 cases.

Known mechanisms ***

The research has moved beyond the level of merely associating silent inflammation with many diseases and conditions. We now also know its  molecular origin: the NLRP3 inflammasome. The activation of this inflammasome starts a molecular cascade affecting virtually all organs.

Accelerates aging ****

Low-Grade Inflammation increases with aging, which is why the term inflammaging was coined about 20 years ago. Inflammaging goes not only along with an increased risk for many diseases, but also with frailty and cognitive decline. All together accelerates aging.

Chronic and not perceivable

In contrast to the beneficial acute inflammation that repairs and heals injuries and comes to a stop after having done its job, low-grade inflammation is not resolved. Unless counteracting measures are undertaken, the inflammation remains chronic and can act for decades - without becoming noticeable.

Source:     

* Bonafè et al. Cytokine & Growth Factor Rev., 53, 33–37, 2020   https://doi.org/10.1016/j.cytogfr.2020.04.005       

** Furman et al. Nat. Med., 25, 1822–1832, 2019  

https://doi.org/10.1038/s41591-019-0675-0

*** Swanson, K.V., Deng, M. & Ting, J.PY. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19, 477–489 (2019

 https://doi.org/10.1038/s41577-019-0165-0

**** Chung, H. Y., Kim, D. H., Lee, E. K., Chung, K. W., Chung, S., Lee, B., Seo, A. Y., Chung, J. H., Jung, Y. S., Im, E., Lee, J., Kim, N. D., Choi, Y. J., Im, D. S., & Yu, B. P. (2019). Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept. Aging and disease, 10(2), 367–382.

https://doi.org/10.14336/AD.2018.0324

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Examples of factors
influencing Low-Grade Chronic Inflammation

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